A Microarray-Based Analysis of Differentially Expressed Genes in Intracellular Brucella abortus 544 within Mdbk Cells
نویسندگان
چکیده
منابع مشابه
Microarray-Based Identification of Differentially Expressed Genes in Intracellular Brucella abortus within RAW264.7 Cells
Brucella spp. is a species of facultative intracellular Gram-negative bacteria that induces abortion and causes sterility in domesticated mammals and chronic undulant fever in humans. Important determinants of Brucella's virulence and potential for chronic infection include the ability to circumvent the host cell's internal surveillance system and the capability to proliferate within dedicated ...
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BACKGROUND Brucellosis is an infectious disease that is caused by Brucella spp. As Brucella spp. are intramacrophage pathogens, the treatment of this infection is very difficult. On the other hand, due to the side effects of the brucellosis treatment regime, it is necessary to find new antimicrobial agents against it. OBJECTIVES The aim of this study was to investigate the antimicrobial effec...
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Here, we present the draft genome sequence and annotation of Brucella abortus virulent strain 544. The genome of this strain is 3,289,405 bp long, with 57.2% G+C content. A total of 3,259 protein-coding genes and 60 RNA genes were predicted.
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The outer membrane proteins (OMPs) of Brucella (B.) abortus have been extensively studied, but their immunogenicity and protective ability against B. abortus infection are still unclear. In the present study, B. abortus Omp28, a group 3 antigen, was amplified by PCR and cloned into a maltose fusion protein expression system. Recombinant Omp28 (rOmp28) was expressed in Escherichia coli and was t...
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The expression profiling of diabetes vs. healthy is a method of identifying genes potentially involved in the pathogenic process. Microarray analysis enable one to determine the relative level of expression of practically all genes in a genome, allowing the prediction of cellular plans for protein synthesis to be established. We therefore took the approach of using microarray analysis to provid...
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ژورنال
عنوان ژورنال: Journal of Ancient Diseases & Preventive Remedies
سال: 2018
ISSN: 2329-8731
DOI: 10.4172/2329-8731.1000181